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PZ0143

PF-4708671

≥98% (HPLC)

Synonym(s):

2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$153.00
25 mg

Available to ship TODAY

$623.00

About This Item

Empirical Formula (Hill Notation):
C19H21F3N6
CAS Number:
Molecular Weight:
390.41
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$153.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

DMSO: ≥20 mg/mL

storage temp.

room temp

SMILES string

CCC(C=NC=N1)=C1N2CCN(CC3=NC4=C(C=CC(C(F)(F)F)=C4)N3)CC2

InChI

1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26)

InChI key

FBLPQCAQRNSVHB-UHFFFAOYSA-N

Gene Information

human ... RPS6KB1(6198)
mouse ... Rps6kb1(72508)
rat ... Rps6kb1(83840)

Biochem/physiol Actions

PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor.
PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor. PF-4708671 inhibits S6K1 with a Ki of 20 nM and IC50 of 160 nM, while having no effect on the closely related RSK and MSK kinases.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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description

≥98% (HPLC)

description

affinity isolated antibody

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

description

clone 1E10, purified immunoglobulin, buffered aqueous solution

form

powder

form

buffered aqueous solution

form

buffered aqueous glycerol solution

form

buffered aqueous solution

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: ≥20 mg/mL

solubility

-

solubility

-

solubility

-

color

off-white

color

-

color

-

color

-


Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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