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S3567

SB 415286

≥98% (HPLC)

Synonym(s):

3-[(3-Chloro-4-hydroxyphenyl)­amino]-4-(2-nitrophenyl)-1H-pyrrol-2,5-dione

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$196.00
$166.60
25 mg

Available to ship TODAYfromMILWAUKEE

$780.00
$663.00

About This Item

Empirical Formula (Hill Notation):
C16H10N3O5Cl
CAS Number:
Molecular Weight:
359.72
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)

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Quality Segment

assay

≥98% (HPLC)

color

yellow to orange

solubility

DMSO: 5 mg/mL, clear, H2O: insoluble

originator

GlaxoSmithKline

storage temp.

−20°C

SMILES string

Oc1ccc(NC2=C(C(=O)NC2=O)c3ccccc3[N+]([O-])=O)cc1Cl

InChI

1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)

InChI key

PQCXVIPXISBFPN-UHFFFAOYSA-N

Gene Information

Application

SB 415286 was used to treat neuroblastoma cells and study the effect of GSK-3 inhibition on cell proliferation.

Biochem/physiol Actions

SB 415286 is a small molecule inhibitor of GSK-3 in muscle and fat cells. SB 415286 induces activation of glycogen synthase and regulates the transport glucose. SB 415286 reduces the systemic inflammation induced by endotoxic shock in rat model of acute colitis. It increases the axonal growth and promotes the recovery of injured adult CNS neurons. SB 415289 is implicated in inducing chromosome instability when used as therapeutic agents.
Glycogen synthase kinase-3 (GSK-3) inhibitor.

Features and Benefits

This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from GlaxoSmithKline.

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This Item
S3442SML1906SML1722
description

≥98% (HPLC)

description

>98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

>98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 5 mg/mL, clear, H2O: insoluble

solubility

DMSO: soluble 20 mg/mL, H2O: insoluble

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

color

yellow to orange

color

orange

color

white to beige

color

white to beige

Gene Information

human ... GSK3A(2931), GSK3B(2932)

Gene Information

human ... GSK3A(2931), GSK3B(2932)

Gene Information

-

Gene Information

-


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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