L-Sulforaphane was used to study Nrf2-mediated signaling in mouse primary preadipocytes6 and murine macrophage RAW 264.7 cell line.7
Biochem/physiol Actions
L-Sulforaphane is a potent, selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.
Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables.3,4 It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.3,5
An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.
description
≥98% (HPLC)
assay
≥95% (HPLC)
assay
≥90% (HPLC)
assay
≥98% (UPLC)
assay
≥98% (HPLC)
form
oil
form
liquid
form
liquid
form
powder
Quality Level
100
Quality Level
200
Quality Level
100
Quality Level
100
storage temp.
−20°C
storage temp.
−20°C
storage temp.
−20°C
storage temp.
2-8°C
solubility
DMSO: >5 mg/mL
solubility
DMSO: soluble 40 mg/mL, H2O: insoluble
solubility
ethanol: 10 mg/mL, DMSO: 20 mg/mL
solubility
DMSO: ≥5 mg/mL
color
light yellow
color
-
color
slight yellow
color
white to beige
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.
