SAE0102
Antithrombin III human
recombinant,carrier-free,expressed in HEK 293 cells
동의어(들):
AT-III, AT3, AT3D, ATIII, ATIII-R2, Factor Xa inhibitor, Heparin cofactor, SERPINC1, Serpin family C member1, Serpin-C1, THPH7
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제품정보 (DICE 배송 시 비용 별도)
NACRES:
NA.41
UNSPSC Code:
12352202
Form:
lyophilized powder
Assay:
≥95% (SDS-PAGE)
Recombinant:
expressed in HEK 293 cells
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
quality
IC50 ≤ 5 nM antithrombin III
impurities
≤1.0 EU/μg (LAL test)
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
General description
Measured by the ability of antithrombin III to inhibit the activity of thrombin in the presence of heparin.
Recombinant human antithrombin III (AT-III) is expressed in human HEK 293 cells as a glycoprotein with a calculated molecular mass of 49 kDa (amino acids 33-464). This protein is manufactured in human cells, with no serum. The human cells expression system allows human-like glycosylation and folding, and often supports higher specific activity of the protein. The protein is produced with no artificial tags.
Application
This recombinant human AT-III product can be used to study the mode of action of the enzyme, as well as its potential inhibitors. It may also be used as a standard, e.g. in antithrombin activity assay, and/or in in vivo studies.
Biochem/physiol Actions
Antithrombin III (AT-III), or Serpin C1 is a serine protease inhibitor glycoprotein, is a member of the Serpin superfamily. Antithrombin III inactivates several components in the coagulation system, IIa,IXa and mainly thrombin and factor Xa. The inhibitory activity of Antithrombin III is potentiated and increased by the polysaccharide heparin. In addition to its abolishment of coagulation, Antithrombin III was also found to suppress proinflammatory mediators, in part by its anticoagulation action. Congenital antithrombin deficiency results in loss of Antithrombin III activity, and leads to thrombosis. Thus, human Antithrombin III enzyme may be prescribed for the treatment and prevention of thromboembolism, as well as for the prevention of perioperative and peripartum thromboembolism.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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이 품목 | |||
|---|---|---|---|
| recombinant expressed in HEK 293 cells | recombinant expressed in HEK 293 cells | recombinant expressed in HEK 293 cells | recombinant expressed in E. coli |
| assay ≥95% (SDS-PAGE) | assay ≥98% (SDS-PAGE) | assay ≥95% (SDS-PAGE) | assay ≥95% (HPLC), ≥95% (SDS-PAGE) |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| shipped in ambient | shipped in - | shipped in - | shipped in wet ice |
| UniProt accession no. | UniProt accession no. - | UniProt accession no. | UniProt accession no. - |
저장 등급
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
관련 콘텐츠
Instructions
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| SAE0102-25UG | 04054839926655 |