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SML0577

Cucurbitacin E

≥95% (HPLC)

Synonym(s):

α-Elaterin, α-Elaterine

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Size/SKUAvailabilityPrice
5 mg
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$227.00
$192.95

About This Item

Empirical Formula (Hill Notation):
C32H44O8
CAS Number:
Molecular Weight:
556.69
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder

$192.95

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Quality Segment

assay

≥95% (HPLC)

form

powder

optical activity

[α]/D -60 to -75°, c = 0.7 (CDCl3)

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

−20°C

InChI

1S/C32H44O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,12-14,19,21-22,25,34-35,39H,11,15-16H2,1-9H3/b13-12+/t19-,21-,22+,25+,29+,30-,31+,32+/m1/s1

InChI key

NDYMQXYDSVBNLL-MUYMLXPFSA-N

Application

Cucurbitacin E has been used as a cofilin inhibitor. It is also used as a F-actin stabilizer to prevent membrane-associated periodic skeleton (MPS) loss and protect from axonal fragmentation.

Biochem/physiol Actions

Cucurbitacin E is a potent inhibitor of actin depolymerization.
Cucurbitacin E is a potent inhibitor of actin depolymerization. Cucurbitacin E is more active than jasplakinolide, and has a different mechanism of action, binding to a different site. Cucurbitacin E binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin), stabilizing F-actin, without affecting actin polymerization or nucleation.

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description

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phyproof® Reference Substance

description

phyproof® Reference Substance

assay

≥95% (HPLC)

assay

≥95.0% (HPLC)

assay

≥85.0% (HPLC)

assay

≥90.0% (HPLC)

form

powder

form

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form

solid

form

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Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 15 mg/mL, clear

solubility

-

solubility

-

solubility

-

color

white to beige

color

-

color

-

color

-


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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