EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca2+) entry (SOC).
EVP4593 is a high affinity partial antagonist of NF-KB pathway activation acting by inhibiting store-operated calcium (Ca2+) entry (SOC). It appears that EVP4593 targets heteromeric channels containing TRPC1 as one of the subunits in HD neurons. EVP4593 exhibits neuroprotective effects from glutamate toxicity in nanomolar concentrations.
The NF-κB Activation Inhibitor, also referenced under CAS 545380-34-5, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
assay
≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
form
solid
Quality Level
100
Quality Level
100
storage temp.
2-8°C
storage temp.
2-8°C
solubility
DMSO: 15 mg/mL, clear
solubility
DMSO: 5 mg/mL
storage condition
desiccated
storage condition
OK to freeze, protect from light
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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