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SML2787

DJ001 (E/Z)

≥98% (HPLC)

Synonym(s):

(2E/Z)-3-[(3-Nitrophenyl)amino]-1-phenyl-2-propen-1-one, (E/Z)-3-((3-nitrophenyl)amino)-1-phenylprop-2-en-1-one, (E/Z)-3-(3-Nitrophenylamino)-1-phenylprop-2-en-1-one, (E/Z)-DJ001, Compound 3071, Compound 5483071

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Size/SKUAvailabilityPrice
5 mg
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$100.00
$85.00
25 mg
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$322.00

About This Item

Empirical Formula (Hill Notation):
C15H12N2O3
CAS Number:
15753-65-8
Molecular Weight:
268.27
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$85.00

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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=CC=CC=C1)/C=C\NC2=CC=CC([N+]([O-])=O)=C2

InChI

1S/C15H12N2O3/c18-15(12-5-2-1-3-6-12)9-10-16-13-7-4-8-14(11-13)17(19)20/h1-11,16H/b10-9-

InChI key

OVTJWWUGQKIRCL-KTKRTIGZSA-N

Biochem/physiol Actions

DJ001 is a selective, allosteric and non-competitive receptor protein tyrosine phosphatase-sigma (PTPσ) inhibitor (IC50 = 1.43 μM; >10 μM/20 other phosphatases) that promotes BM hematopoietic stem/progenitor cells (HSPCs) expansion (0.1-1 μg/mL or 0.373-3.73 μM; murine CD34- KSL cells) and suppresses radiation-induced BM HSC apoptosis (1-5 μg/mL; murine KSL & human CD34+ cells) via RhoGTPase/RAC1 activation and BCL-XL induction. DJ001 accelerates hematologic recovery and improves survival of irradiated mice in vivo (5 mg/kg/d s.c.). The (Z)- & (E)-isomers exist in equilibrium in polar solvents with (Z) showing enhanced binding-affinity to PTPσ catalytic & allosteric sites.
Selective, allosteric receptor protein tyrosine phosphatase-sigma (PTPσ) inhibitor that promotes BM hematopoietic stem/progenitor cells (HSPCs) expansion in vitro & in vivo.

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This Item
SML2544SML1981SML2365
DJ001 (E/Z) ≥98% (HPLC)

Sigma-Aldrich

SML2787

DJ001 (E/Z)

NSC49652 ≥98% (HPLC)

Sigma-Aldrich

SML2544

NSC49652

NIBR189 ≥98% (HPLC)

Sigma-Aldrich

SML1981

NIBR189

Phenprocoumon ≥97% (HPLC)

Sigma-Aldrich

SML2365

Phenprocoumon

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥97% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥97% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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