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SML3340

Sgl1 inhibitor Hit 1

≥98% (HPLC)

Synonym(s):

4-Hydroxy-1-[[2-(3-methoxyphenyl)-5-thiazolyl]methyl]-4-piperidinemethanol

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About This Item

Empirical Formula (Hill Notation):
C17H22N2O3S
CAS Number:
1332191-15-7
Molecular Weight:
334.43
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

COC1=CC=CC(C2=NC=C(S2)CN3CCC(O)(CC3)CO)=C1

InChI key

FXCZNKJONOHACS-UHFFFAOYSA-N

Biochem/physiol Actions

Cell penetrant, potent and low toxic inhibitor of Cryptococcus neoformans sterylglucosidase 1 (Sgl1)
Sgl1 inhibitor Hit 1 is a cell penetrant, potent and low toxic inhibitor of Cryptococcus neoformans sterylglucosidase 1 (Sgl1) that significantly increases in the intracellular concentration of ergosterol 3β-D-glucoside (erg-glc). Sgl1 inhibitor Hit 1 potently inhibits growth of wild-type C. neoformans. Also, it inhibits brain dissemination of C. neoformans in a mouse model of infection.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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