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SML3365

MZ1

≥98% (HPLC)

Synonym(s):

(2S,4R)-1-((2S)-2-tert-Butyl-17-((6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecane)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (2S,4R)-1-((S)-1-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-17,17-dimethyl-2,14-dioxo-6,9,12-trioxa-3,15-diazaoctadecanecarbonyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (4R)-N-[14-[(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-1,13-dioxo-3,6,9-trioxa-12-azatetradec-1-yl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, MZ 1, MZ 1 (PROTAC)

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
$165.00
25 mg
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$661.00

About This Item

Empirical Formula (Hill Notation):
C49H60ClN9O8S2
CAS Number:
Molecular Weight:
1002.64
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$165.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(COCCOCCOCCNC(C[C@H]2C3=NN=C(N3C4=C(C(C5=CC=C(C=C5)Cl)=N2)C(C)=C(S4)C)C)=O)=O)=O)NCC6=CC=C(C=C6)C7=C(N=CS7)C

InChI key

PTAMRJLIOCHJMQ-PYNGZGNASA-N

Biochem/physiol Actions

BRD4 degrader
MZ1 is a BRD4 degrader composed of pan-BET selective bromodomain inhibitor and the E3 ubiquitin ligase VHL ligand that induces preferential degradation of BRD4 over BRD2 and BRD3. MZ1exhibits antiproliferative effects in AML colorectal cancer cells lines.

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1 of 1

This Item
SML3565SML3323SML3324
assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

-

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

-10 to -25°C

storage temp.

-10 to -25°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear (Warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (Warmed)

color

white to beige

color

white to beige

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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