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SML3370

BI605906

≥98% (HPLC)

Synonym(s):

3-Amino-4-(1,1-difluoro-propyl)-6-(4-methanesulfonyl-piperidin-1-yl)-thieno[2,3-b]pyridine-2-carboxylic acid amide, 3-Amino-4-(1,1-difluoropropyl)-6-[4-(methylsulfonyl)-1-piperidinyl]-thieno[2,3-b]pyridine-2-carboxamide, BI 605906, BI-605906

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Pack SizeSKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
€87.50
25 mg
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€352.00

About This Item

Empirical Formula (Hill Notation):
C17H22F2N4O3S2
CAS Number:
960293-88-3
Molecular Weight:
432.51
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD22665698
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

€87.50

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

, White to very dark gray

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

CCC(F)(C1=C2C(SC(C(N)=O)=C2N)=NC(N3CCC(CC3)S(C)(=O)=O)=C1)F

InChI

1S/C17H22F2N4O3S2/c1-3-17(18,19)10-8-11(23-6-4-9(5-7-23)28(2,25)26)22-16-12(10)13(20)14(27-16)15(21)24/h8-9H,3-7,20H2,1-2H3,(H2,21,24)

InChI key

IYHHRZBKXXKDDY-UHFFFAOYSA-N

Biochem/physiol Actions

BI605906 is a selective, ATP-competitive IκB kinase β (IKK2, IKKβ, IKK-beta) inhibitor (IC50 = 380 nM, [ATP] = 0.1 mM) with no potency toward 100 other kinases, including IKKα, IKKε, TBK1, and IGF1R (IC50 ≥7.6 µM). BI605906 (10 µM) effectively blocks IKK-β-dependent phosphorylation of IKKε and TBK1 in IKKα-/- MEFs upon IL-1α (5 ng/mL) induction.
Sective, ATP-competitive IκB kinase β (IKK2, IKKβ, IKK-beta) inhibitor with no potency toward 100 other kinases, including IKKα, IKKε, TBK1, and IGF1R.

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BI605906 ≥98% (HPLC)

Sigma-Aldrich

SML3370

BI605906

BI-5026 ≥98% (HPLC)

Sigma-Aldrich

SML3239

BI-5026

FDI-6 ≥98% (HPLC)

Sigma-Aldrich

SML1392

FDI-6

VU0152100 ≥98% (HPLC)

Sigma-Aldrich

V5015

VU0152100

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder (flocculent)

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: >50 mg/mL

color

, White to very dark gray

color

white to beige

color

white to beige

color

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Amy R Cameron et al.
Circulation research, 119(5), 652-665 (2016-07-16)
The diabetes mellitus drug metformin is under investigation in cardiovascular disease, but the molecular mechanisms underlying possible benefits are poorly understood. Here, we have studied anti-inflammatory effects of the drug and their relationship to antihyperglycemic properties. In primary hepatocytes from
Kristopher Clark et al.
The Biochemical journal, 434(1), 93-104 (2010-12-09)
Members of the IKK {IκB [inhibitor of NF-κB (nuclear factor κB)] kinase} family play a central role in innate immunity by inducing NF-κB- and IRF [IFN (interferon) regulatory factor]-dependent gene transcription programmes required for the production of pro-inflammatory cytokines and
Raid B Nisr et al.
Cellular and molecular life sciences : CMLS, 76(24), 4887-4904 (2019-05-19)
Sustained nutrient (fuel) excess, as occurs during obesity and diabetes, has been linked to increased inflammation, impaired mitochondrial homeostasis, lipotoxicity, and insulin resistance in skeletal muscle. Precisely how mitochondrial dysfunction is initiated and whether it contributes to insulin resistance in

Global Trade Item Number

SKUGTIN
SML3370-5MG04065268435304
SML3370-25MG04065268435298

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