Skip to Content
Merck

Skip To

SML3375

WYE-687

≥98% (HPLC)

Synonym(s):

Methyl (4-{4-Morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl}phenyl)carbamate, Methyl N-[4-[4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamate, WAY 687, WAY-687, WAY687, WYE 687, WYE687

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice

About This Item

Empirical Formula (Hill Notation):
C28H32N8O3
CAS Number:
Molecular Weight:
528.61
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N2(CCC(CC2)[n]3ncc4c3nc(nc4N6CCOCC6)c5ccc(cc5)NC(=O)OC)Cc1cnccc1

InChI

1S/C28H32N8O3/c1-38-28(37)31-22-6-4-21(5-7-22)25-32-26(35-13-15-39-16-14-35)24-18-30-36(27(24)33-25)23-8-11-34(12-9-23)19-20-3-2-10-29-17-20/h2-7,10,17-18,23H,8-9,11-16,19H2,1H3,(H,31,37)

InChI key

VDOCQQKGPJENHJ-UHFFFAOYSA-N

Biochem/physiol Actions

ATP-competitive, potent and selective mTOR inhibitor.
WYE-687 is an ATP-competitive, potent and selective mTOR inhibitor (IC50 = 7 nM; [ATP] = 100 μM) with much reduced or little potency toward other kinases (PI3Kα/PI3Kγ/CK1 γ1/p38α IC50 = 0.81/3.11/17.8/28.9 μM; IC50 >50 μM toward 22 other kinases). WYE-687 selectively inhibits IGF-I-stimulated phosphorylation of S6K1 pT389 over those of AKT pS473 & pS308 in Rat1 cells (0.3 nM), as well as suppresses mTOR-dependent proliferation in cancer cultures (PC3MM2/MDA-MB-361/LNCaP/A498 IC50 = 180/200/350/620 nM).

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
SML3153SML3560SML3101
form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (warmed)

color

white to beige

color

white to beige

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library



Questions

Reviews

No rating value

Active Filters