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SML3384

Cyclovirobuxine D

≥90% (HPLC)

Synonym(s):

(3α,5α,16α,20S)-4,4,14-Trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol, (3β,5α,16α,20S)-4,4,14-trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol, Bebuxine, CVB-D

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About This Item

Empirical Formula (Hill Notation):
C26H46N2O
CAS Number:
860-79-7
Molecular Weight:
402.66
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
MFCD00468040
Assay:
≥90% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥90% (HPLC)

form

powder

color

white to beige

solubility

0.1 M HCl: 2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

C[C@H](NC)[C@@]1([H])[C@H](O)C[C@@]2(C)[C@]3([H])CC[C@@]4([H])C(C)(C)[C@@H](NC)CC[C@]4(C5)[C@]35CC[C@@]21C

InChI

1S/C26H46N2O/c1-16(27-6)21-17(29)14-24(5)19-9-8-18-22(2,3)20(28-7)10-11-25(18)15-26(19,25)13-12-23(21,24)4/h16-21,27-29H,8-15H2,1-7H3/t16-,17+,18-,19-,20-,21-,23+,24-,25+,26-/m0/s1

InChI key

GMNAPBAUIVITMI-ABNIRSKTSA-N

Biochem/physiol Actions

Cyclovirobuxine D is a steroidal alkaloid component extracted from the root of medical plant Buxus microphylla that exhibits beneficial effect on heart failure, arrhythmias, myocardial ischemia and other cardiovascular diseases. Apparently it increases the release and uptake of Ca(2+) in systolic and diastolic periods. Cyclovirobuxine D induces mitochondria-mediated apoptosis in numerous cancer cells including breast and gastric cancer cells. It induces autophagy-associated cell death via the Akt/mTOR pathway in human breast cancer cells.
Steroidal alkaloid component extracted from the root of medical plant Buxus microphylla that exhibits beneficial effect on cardiovascular diseases

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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