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MilliporeSigma

SML3582

TAM16

≥98% (HPLC)

Synonym(s):

5-​Hydroxy-​2-​(4-​hydroxyphenyl)​-​N-​methyl-​4-​(1-​piperidinylmethyl)​-3-​benzofurancarboxamid​e

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About This Item

Empirical Formula (Hill Notation):
C22H24N2O4
CAS Number:
Molecular Weight:
380.44
UNSPSC Code:
12352200
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(C1=C(OC2=CC=C(C(CN3CCCCC3)=C21)O)C4=CC=C(C=C4)O)NC

InChI

1S/C22H24N2O4/c1-23-22(27)20-19-16(13-24-11-3-2-4-12-24)17(26)9-10-18(19)28-21(20)14-5-7-15(25)8-6-14/h5-10,25-26H,2-4,11-13H2,1H3,(H,23,27)

InChI key

PQGCMFVNJWTUFH-UHFFFAOYSA-N

Biochem/physiol Actions

Potent and selective inhibitor of the thioesterase activity of Mycobacterium tuberculosis polyketide synthase Pks13
TAM16 is a potent and selective inhibitor of the thioesterase activity of Mycobacterium tuberculosis polyketide synthase Pks13. TAM16 is a highly potent bactericidal agent that exhibits activity against drug-susceptible and drug-resistant clinical isolates of M. tuberculosis. It is effective in both acute and chronic mouse TB models.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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