SML3588
J147
≥98% (HPLC)
Synonym(s):
(E)-N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N′-(3-methoxybenzylidene)acetohydrazide, 2,2,2-Trifluoro-acetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide, J 147
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About This Item
Empirical Formula (Hill Notation):
C18H17F3N2O2
CAS Number:
Molecular Weight:
350.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
SMILES string
COC1=CC(/C=N/N(C2=C(C=C(C=C2)C)C)C(C(F)(F)F)=O)=CC=C1
InChI
1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+
InChI key
HYMZAYGFKNNHDN-SSDVNMTOSA-N
Biochem/physiol Actions
Broadly neuroprotective agent that enhances the memory in normal and Alzheimer’s disease (AD) transgenic mice
J147 is a broadly neuroprotective (in multiple assays) compound that enhances the memory in normal and Alzheimer’s disease (AD) transgenic mice. J147 has neurotrophic and BDNF-like activities that are independent of the BDNF receptor, and TrkB. Also it appears that J147 has a small but significant effect on Ab metabolism by reducing Ab1–42 in the soluble fraction of the hippocampus.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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