SML3659
SJB2-043
≥98% (HPLC)
Synonym(s):
2-Phenyl-naphth[2,3-d]oxazole-4,9-dione
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About This Item
Empirical Formula (Hill Notation):
C17H9NO3
CAS Number:
Molecular Weight:
275.26
UNSPSC Code:
12352200
NACRES:
NA.25
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
, Faint green to yellow
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
SMILES string
n1c2c([o]c1c4ccccc4)C(=O)c3c(cccc3)C2=O
InChI
1S/C17H9NO3/c19-14-11-8-4-5-9-12(11)15(20)16-13(14)18-17(21-16)10-6-2-1-3-7-10/h1-9H
InChI key
CMYQQADDUUDCCA-UHFFFAOYSA-N
Biochem/physiol Actions
SJB2-043 is a ubiquitin-specific protease USP1 inhibitor (IC50 = 544 nM using USP1/UAF1 complex) that exhibits anti-proliferation efficacy against chronic and acute myeloid leukemia lines (IC50 <2 µM; K562, OCI-AML3, SK-NO1, U937) and primary acute myelogenous leukemia (AML) patient-derived leukemic cells by promoting the degradation of transcription factor DNA binding 1 (ID1). SJB2-043 is also reported to be an allosteric site-targeting inhibitor against PLPro (IC50 = 0.56 μM), the papain-like cysteine protease with deubiquitination and deISGylation activities that suppress host innate immune responses toward SARS-CoV-2 infection.
Ubiquitin-specific protease USP1 inhibitor with anti-leukemia efficacy. Also reported to inhibit SARS-CoV-2 papain-like cysteine protease PLPro.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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