SML3776
AZD1080
≥98% (HPLC)
Synonym(s):
2-Hydroxy-3-[5-(4-morpholinylmethyl)-2-pyridinyl]-1H-indole-5-carbonitrile, 2-Hydroxy-3-[5-[(morpholin-4-yl)methyl]pyridin-2-yl]-1H-indole-5-carbonitrile, AZ1080, AZD 1080
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About This Item
Empirical Formula (Hill Notation):
C19H18N4O2
CAS Number:
Molecular Weight:
334.37
UNSPSC Code:
12352200
NACRES:
NA.21
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
, Faint yellow to yellow brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
SMILES string
N4(CCOCC4)Cc1cnc(cc1)c2c3c([nH]c2O)ccc(c3)C#N
InChI
1S/C19H18N4O2/c20-10-13-1-3-16-15(9-13)18(19(24)22-16)17-4-2-14(11-21-17)12-23-5-7-25-8-6-23/h1-4,9,11,22,24H,5-8,12H2
InChI key
BLTVBQXJFVRPFK-UHFFFAOYSA-N
Biochem/physiol Actions
AZ1080 is a brain penetrant, orally bioavailable, potent and selective glycogen synthase kinase (GSK3) inhibitor that reduce pcdc1 (PD-1) transcription and expression. AZ1080 enhances CD8+ T-cell function in cancer, and is as effective as ant-PD-1 in controlling of B16 melanoma and EL4 lymphoma growth in mice.
Brain penetrant, orally bioavailable, potent and selective glycogen synthase kinase (GSK3) inhibitor that reduce pcdc1 (PD-1) transcription and expression
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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