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SML3860

Conolidine

≥98% (HPLC)

Synonym(s):

(+)-Conolidine, (+)-Ervaticine, (2R,4E,5S)-4-Ethylidene-1,4,5,7-tetrahydro-2,5-ethano-2H-azocino[4,3-b]indol-6(3H)-one, Ervaticine

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About This Item

Empirical Formula (Hill Notation):
C17H18N2O
CAS Number:
100414-81-1
Molecular Weight:
266.34
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >2 mg/mL, clear

storage temp.

-10 to -25°C

SMILES string

O=C(C1=C(C[N@](CC2)C/3)C4=C(C=CC=C4)N1)[C@@H]2C3=C(C)\[H]

InChI

1S/C17H18N2O/c1-2-11-9-19-8-7-12(11)17(20)16-14(10-19)13-5-3-4-6-15(13)18-16/h2-6,12,18H,7-10H2,1H3/b11-2-/t12-/m0/s1

InChI key

DBGBUYFOJXOYNY-RENATIMJSA-N

Biochem/physiol Actions

Natural analgesic that induces pain relieve though activation of atypical scavenger receptor for chemokines and opioid peptides ACKR3 (CXCR7).



Conolidine is a natural analgesic isolated from tropical flowering shrub Tabernaemontana divaricate, which exhibits potent analgesia in in vivo models of tonic and persistent pain. Conolidine induces pain relieve though activation of atypical scavenger receptor for chemokines and opioid peptides ACKR3 (CXCR7). It appears that conolidine inhibits scavenging functions of ACKR3 therefore increasing levels of endogenous opioid peptides.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

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