Skip to Content

Key Documents

View All Documentation

SML3875

Usp22i-S02

≥98% (HPLC)

Synonym(s):

7,8,9,10-Tetrahydro-11-(phenylamino)benzimidazo[1,2-b]isoquinoline-6-carbonitrile, S02, USP22-IN-1

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C22H18N4
CAS Number:
309735-96-4
Molecular Weight:
338.41
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD01038485
Assay:
≥98% (HPLC)
Form:
powder
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

Cell-permeable and potent inhibitor of ubiquitin specific peptidase 22 (USP22) that exhibits anticancer activity.


Usp22i-S02 is a cell-permeable benzimidazoisoquinoline-carbonitrile analog that is shown to reversibly occupy USP22 (ubiquitin specific peptidase 22) catalytic domain and suppress its functions. Usp22i-S02 arrests Usp22-mediated Foxp3 deubiquitination in iTREG cells in a time and dose-dependent manner. Usp22i-S02 administration enhances antitumor immunity with low toxicity in LLC1-challenged mice (20 mg/kg) and reduces tumor burden in a Treg-specific manner. immunity with low toxicity in LLC1-challenged mice (20 mg/kg) and reduces tumor burden in a Treg-specific manner.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library