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SML3909

SGC-CK2-2

≥98% (HPLC)

Synonym(s):

5-(Benzylamino)pyrimido[4,5-c]quinoline-8-carboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C19H14N4O2
CAS Number:
2825012-70-0
Molecular Weight:
330.34
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD35067914
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Highly potent and selective casein kinase 2 (CK2, CKII) inhibitor that inhibits downstream AKT S129 phosphorylation in MDA-MB-231 cells
SGC-CK2-2 is a highly potent and selective casein kinase 2 (CK2, CKII) inhibitor (IC50 = 3 nM/CK2α and <1 nM/CK2α by enzyme assay; CK2α/CK2α′ IC50 = 920/200 nM by cellular NanoBRET; genomewide by DiscoverX scanMAX panel at 1 μM). SGC-CK2-2 effectively inhibits CK2 downstream signaling in MDA-MB-231 cells (AKT pS129 IC50 ~5 μM post 24h) without cytotoxicity (up to 10 μM & 48h).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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