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About This Item
Empirical Formula (Hill Notation):
C25H31N5O4
CAS Number:
Molecular Weight:
465.54
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(C1=CC=C(NC(NCCN2CCOCC2)=O)C=C1)/C=C/C3=CC=CC(N4CCOCC4)=N3
Biochem/physiol Actions
Potent heat shock protein 70 inducer with therapeutic efficacy in a rat model of transient cerebral ischemia in vivo.
TRC051384 is a potent heat shock protein 70 inducer (fold of HSP70 mRNA induction in 4h at 6.25/12.5 µM = 19/210 in HeLa & 10/84 in primary neonatal rat cerebellum neurons) that increases HSF1 transcriptional activity in HeLa cells (by 2.1/3.3-fold at 12.5/2.5 µM) and reduces LPS-induced TNF-α expression in THP-1 cells (% inhibition/conc. = 60/6.25 µM & 90/12.5 µM). TRC051384 reduces neuronal injury and disability in a rat model of transient cerebral ischemia in vivo (9 mg/kg 4h or 8h post onset of ischemia, then 4.5 mg/kg every 2h for 48h via i.p.).
TRC051384 is a potent heat shock protein 70 inducer (fold of HSP70 mRNA induction in 4h at 6.25/12.5 µM = 19/210 in HeLa & 10/84 in primary neonatal rat cerebellum neurons) that increases HSF1 transcriptional activity in HeLa cells (by 2.1/3.3-fold at 12.5/2.5 µM) and reduces LPS-induced TNF-α expression in THP-1 cells (% inhibition/conc. = 60/6.25 µM & 90/12.5 µM). TRC051384 reduces neuronal injury and disability in a rat model of transient cerebral ischemia in vivo (9 mg/kg 4h or 8h post onset of ischemia, then 4.5 mg/kg every 2h for 48h via i.p.).
Storage Class
11 - Combustible Solids
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