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About This Item
Empirical Formula (Hill Notation):
C20H19N4O3·Br
CAS Number:
Molecular Weight:
443.29
MDL number:
NACRES:
NA.28
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
-10 to -25°C
Biochem/physiol Actions
Survivin expression inhibitor with anti-cancer efficacy in cultures and in vivo.
YM155 is a survivin expression inhibitor (effective conc. 10-100 nM for 6-48h; PC-3 & PCC-1 cells) that induces apoptosis in malignant melanoma and hormone-refractory prostate cancer (HRPC) cultures (GI50 = 2.3-11 nM) by targeting survivin gene promoter activity without affecting the expression of other IAPs or Bcl-2-related proteins even at concentrations as high as 100 nM. In a s.c. xenografted PC-3 tumor model in mice, 3-day continuous infusions of YM155 at 3 to 10 mg/kg induced massive tumor regression in vivo.
YM155 is a survivin expression inhibitor (effective conc. 10-100 nM for 6-48h; PC-3 & PCC-1 cells) that induces apoptosis in malignant melanoma and hormone-refractory prostate cancer (HRPC) cultures (GI50 = 2.3-11 nM) by targeting survivin gene promoter activity without affecting the expression of other IAPs or Bcl-2-related proteins even at concentrations as high as 100 nM. In a s.c. xenografted PC-3 tumor model in mice, 3-day continuous infusions of YM155 at 3 to 10 mg/kg induced massive tumor regression in vivo.
Disclaimer
Hygroscopic
Storage Class
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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