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About This Item
Empirical Formula (Hill Notation):
C34H50N4O9S
CAS Number:
Molecular Weight:
690.85
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
powder
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Dalfopristin is a semisynthetic polyunsaturated macrolactone type II streptogramin antibiotic protein synthesis inhibitor. It is generally used in combination with Quinupristin. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis, thus the two together act synergistically. Dalfopristin binds to the 23S portion of the 50S ribosomal subunit, and changes the conformation, enhancing the binding of quinupristin. In addition, it inhibits peptidyl transfer. Quinupristin binds to a nearby site on the 50S ribosomal subunit and prevents elongation of the polypeptide, as well as causing incomplete chains to be released. Each alone is only bacteriostatic; the combination is bactericidal.
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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