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SML4153

JPH203 hydrochloride

≥97% (HPLC)

Synonym(s):

(S)-2-Amino-3-(4-((5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy)-3,5-dichlorophenyl)propanoic acid dihydrochloride, JPH 203, dihydrochloride, JPH-203, dihydrochloride, KYT 0353, dihydrochloride, KYT-0353, dihydrochloride, KYT0353, dihydrochloride, Nanvuranlat, dihydrochloride, O-(5-Amino-2-phenylbenzoxazole-7-yl)methyl-3,5-dichloro-L-tyrosine dihydrochloride, O-[(5-Amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine dihydrochloride, SCHEMBL17360639, dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C23H19Cl2N3O4 · xHCl
CAS Number:
2417321-18-5
Molecular Weight:
472.32 (free base basis)
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

JPH203 (KYT-0353; Nanvuranlat) selectively inhibits L-type amino acid transporter LAT1-dependent L-leucine uptake and growth in HT-29 (IC50/GI50 = 0.06/4.1 μM) and human LAT1-expressing S2 murine renal proximal tubule cell cultures (IC50/GI50 = 0.14/16.4 μM), but not human LAT2-expressing S2 cells (IC50 >10, GI50 >1000 μM). When administered via intravenous injection, JPH203 effectively inhibits HT-29-derived tumor growth in mice in vivo (6.3-25 mg/kg via daily i.v. from d0 to d13).

Disclaimer

Hygroscopic, Store with desiccant

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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