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SML4233

Perampanel

≥98% (HPLC)

Synonym(s):

2-(1′,6′-Dihydro-6′-oxo-1′-phenyl[2,3′-bipyridin]-5′-yl)-benzonitrile; 2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl) benzonitrile, E 2007, E-2007, E2007

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About This Item

Empirical Formula (Hill Notation):
C23H15N3O
CAS Number:
380917-97-5
Molecular Weight:
349.38
MDL number:
MFCD19443693
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

drug control

USDEA Schedule III

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

Perampanel is an orally active, noncompetitive AMPA receptor antagonist that inhibits 2 μM AMPA-, but not NMDA-, induced Ca2+ in cultured rat cortical neurones (IC50 = 93 nM) and display therapeutic efficacy in murine models of epilepsy in vivo (audiogenic, MES-induced, and PTZ-induced seizures in mice ED50 = 0.47, 1.6, and 0.94 mg/kg p.o., respectively) and a rat amygdala-kindling model (1-10 mg/kg p.o.).

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H413

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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