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SML4244

GSK0660

≥98% (HPLC), powder, PPARβ/δ antagonist

Synonym(s):

3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester, Methyl 3-({[2-(methoxy)-4 phenyl]amino}sulfonyl)-2-thiophenecarboxylate, GSK 0660, GSK-0660

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About This Item

Empirical Formula (Hill Notation):
C19H18N2O5S2
CAS Number:
1014691-61-2
Molecular Weight:
418.49
MDL number:
MFCD12828770
NACRES:
NA.21
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Application

GSK0660 may be used in cell viability assay, real time cell index analysis, and oxyblot assays to study its neuroprotective effect on Parkinson’s disease model in vivo and in vitro.

Biochem/physiol Actions

GSK0660 is a potent and selective peroxisome proliferator-activated receptor delta (PPARdelta) and PPARbeta antagonist (IC50 = 300 nM against GW1516-induced PPARβ/δ reporter activity; IC50 = 155 nM vs >10 µM for PPARα and PPARγ by GW1516 displacement binding assays). GSK0660 effectively antagonizes PPARβ/δ agonist GW501516 (GW1516)-induced target genes expression in multiple cell types, including HuH7, rat L6 myotubes, and mouse BMDMs (1-10 nM GW1516, 100-1000 nM GSK0660).

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

No data available

flash_point_c

No data available

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