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SML4258

Spexin 1 trifluoroacetate

≥95% (HPLC), (Powder or Lyophilized powder or film), GAL2/3 agonist

Synonym(s):

H-Asn-Trp-Thr-Pro-Gln-Ala-Met-Leu-Tyr-Leu-Lys-Gly-Ala-Gln-NH₂ trifluoroacetate, L-Asparaginyl-L-tryptophyl-L-threonyl-L-prolyl-L-glutaminyl-L-alanyl-L-methionyl-L-leucyl-L-tyrosyl-L-leucyl-L-lysylglycyl-L-alanyl-L-glutamamide trifluoroacetate, Spexin trifluoroacetate, SPX trifluoroacetate, SPX1 trifluoroacetate, Neuropeptide Q trifluoroacetate, NPQ trifluoroacetate, NPQ 53-70 trifluoroacetate, NWTPQAMLYLKGAQ-NH2 trifluoroacetate

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About This Item

Empirical Formula (Hill Notation):
C74H114N20O19S · xC2HF3O2
CAS Number:
1370290-58-6
Molecular Weight:
1619.88 (free base basis)
Assay:
≥95% (HPLC)
Form:
(Powder or Lyophilized powder or film)
Storage condition:
desiccated
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Quality Segment

100

assay

≥95% (HPLC)

form

(Powder or Lyophilized powder or film)

storage condition

desiccated

color

white to off-white

storage temp.

-10 to -25°C

General description

Spexin is a 4-amino acidpeptide, produced by neurons in the hypothalamus.

Application

Spexin for its potential roles in regulating appetite and metabolism,influencing reproductive hormones, in metabolic and endocrine research.

Biochem/physiol Actions

Spexin 1 (SPX) is a 14-aa amidated peptide that acts as an endogenousgalanin receptor GAL2/3 agonist (EC50 = 161 nM/GAL2, 626 nM/GAL3, >10µM/GAL1 by reporter assays using respective HEK293 transfectants) that inhibits facilitated fatty acid (FA) uptake in diet-induced obesity (DIO) mouse adipocytes cultures (0.1-1 ng/mL) and induces rat stomach muscle contraction ex vivo (EC50 = 750 nM). SPX reduces caloric intake in rats (∼32%; 35 µg/kg/day s.c.) with corresponding weight loss and significantly reduces the RER at night as well as increases locomotion in mice in vivo (25 µg/kg/day i.p.). Note: peptide sequence is conserved in human, murine, rat and many other mammalian species.

Disclaimer

Hygroscopic Store with desiccant

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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