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SML4284

Fumarate hydratase-IN-1

Name: Fumarate hydratase-IN-1
Brand: SIGMA

≥98% (HPLC), powder, fumarate hydratase inhibitor

Synonym(s):

rel- Ethyl (3S,3aR)-1-([1,1′-biphenyl]-4-ylmethyl)-3-(2-(methylamino)-2-oxoethyl)-2-oxo-1,2,3,4,5,6-hexahydro-3aH-indole-3a-carboxylate

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About This Item

Empirical Formula (Hill Notation):

C₂₇H₃₀N₂O₄

CAS Number:

1644060-37-6

Molecular Weight:

446.54

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Description

Application

Fumarate hydratase-IN-1 may be used:

to study its effects on mitochondrial bioenergetics and macrophage metabolism
to assess its regulatory effects in LPS-induced acute lung injury (ALI) models
to study the role of fumarate in immunomodulation and regulating type I interferon production after viral infection

Biochem/physiol Actions

FHIN1 exhibits nutrient-dependent antiproliferation activity in cancer cultures (mean IC50 = 2.2 µM in glucose-free L-15 medium; SW620, ACHN, HCT-116, PC3, SK-MEL-28) by targeting tricarboxylic acid (TCA) cycle without blocking mitochondrial electron-transport chain (ETC) or ATP synthase.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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