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SML4285

GPX4 Inhibitor A16

≥98% (HPLC), powder, glutathione peroxidase 4 inhibitor

Synonym(s):

A16, Benzenesulfonamide, 4-[[[4-(2-benzothiazolyl)phenyl]-2-propyn-1-ylamino]methyl]-N-ethynyl-N-methyl

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About This Item

Empirical Formula (Hill Notation):
C26H21N3O2S2
CAS Number:
3032746-99-6
Molecular Weight:
471.59
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Application

GPX4 Inhibitor A16 may be used in proteomics research to study GPX4 function in in situ and in vivo conditions and explore the therapeutic potential of pancreatic cancer via ferroptosis induction.

Biochem/physiol Actions

GPX4 Inhibitor A16, equipped with a cysteine reactive warhead ynamide, is a highly potent and selective covalent inhibitor of glutathione peroxidase 4 (GPX4), surpassing existing inhibitors like ML210 and ML162 in its ability to induce ferroptosis in cancer cells through GPX4 inhibition. With its wide-ranging effectiveness across various cell lines (IC50: 0.02-0.2 μM) and significant in vivo (10 mg/kg, i.p., in AsPC-1 xenograft mouse model) anticancer activity coupled with a favorable safety profile, A16′s mechanism, verified by chemical proteomics and ferrostatin-1 rescue assays, demonstrates its considerable therapeutic potential by targeting the GPX4-dependent ferroptosis pathway.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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