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SML4299

TAK-448 acetate salt

≥95% (HPLC), (Powder or Lyophilized powder or film), kisspeptin agonist

Synonym(s):

Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 acetate, N-Acetyl-D-tyrosyl-(4R)-4-hydroxy-L-prolyl-L-asparaginyl-L-threonyl-L-phenylalanyl-2-azaglycyl-L-leucyl-N5-[imino(methylamino)methyl]-L-ornithyl-L-tryptophanamide acetate

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About This Item

Empirical Formula (Hill Notation):
C58H80N16O14 · xC2H4O2
Molecular Weight:
1225.35 (free base basis)
Assay:
≥95% (HPLC)
Form:
(Powder or Lyophilized powder or film)
Storage condition:
desiccated
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Quality Segment

100

assay

≥95% (HPLC)

form

(Powder or Lyophilized powder or film)

storage condition

desiccated

color

white to off-white

storage temp.

-10 to -25°C

General description

RVT-602 (TAK-448) is a Kisspeptin analog. It is a nonapeptide, ending with Arg-Trp-NH2 sequence.

Application

TAK-448 may be used to investigate its pharmacodynamic properties through receptor binding and agonistic assays, and to assess its impact on plasma drug and testosterone levels in rat models.

Biochem/physiol Actions

TAK-448 acts by stimulatiing stimulating GnRH secretion, increasing the release of LH and FSH. Sustained exposure results in a transient increase in plasma testosterone followed by potent suppression of testosterone levels.

Disclaimer

Hygroscopic Store with desiccant

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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