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SML4323

Apatinib

≥98% (HPLC)

Synonym(s):

N-[4-(1-Cyanocyclopentyl)phenyl]-2-[(4-pyridinylmethyl)amino]-3-pyridinecarboxamide, N-[4-(1-cyanocyclopentyl)phenyl]-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide, Rivoceranib, YN 968D1

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About This Item

Empirical Formula (Hill Notation):
C24H23N5O
CAS Number:
811803-05-1
Molecular Weight:
397.47
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

Apatinib (rivoceranib) is an orally available, potent, and selective inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2) (IC50 = 1 nM) that potently blocks tumor angiogenesis and inhibits tumor growth. Apatinib exhibits encouraging antitumor efficacy and acceptable toxicities in multiple clinical trials. It also mildly targets c-Kit and c-SRC tyrosine kinases.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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