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About This Item
Empirical Formula (Hill Notation):
C7H8O5
CAS Number:
Molecular Weight:
172.14
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
MMF prodrug-1c is a cell permeable activator of NRF2. A site-specific monomethyl fumarate (MMF) prodrug (1c) achieves targeted delivery of MMF through a peroxide-dependent Baeyer-Villiger oxidation mechanism, selectively activating NRF2 at sites of pathological oxidative stress. Upon oral administration, MMF prodrug-1c rapidly converts to a stable glutathione S-conjugate that circulates until encountering elevated peroxide concentrations (>1 μM H2O2 or >20 μM peroxynitrite) at disease sites, where it releases therapeutic MMF while avoiding indiscriminate NRF2 activation in healthy tissues. At an optimal dose of 350 μmol/kg/day, MMF prodrug-1c demonstrates superior efficacy to conventional MMF delivery in multiple chronic pain models, reversing peripheral neuropathy, osteoarthritis, and chemotherapy-induced neuropathic pain without inducing systemic side effects like glutathione depletion or cutaneous flushing.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Sens. 1
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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