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About This Item
Empirical Formula (Hill Notation):
C21H20F7N3O4S
CAS Number:
Molecular Weight:
543.46
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Bitopertin (RG1678) is an orally available, potent (IC50=30nM) and selective inhibitor of glycine transporter GlyT1. Glycine transporters remove the neurtransmitter glycine from the synapse; their inhibition prolongs glycine transmission. GlyT1 inhibitors increase levels of glycine in the synaptic cleft leading to positive modulation of glutamatergic N-methyl-D-aspartate (NMDA) receptor function since glycine is a co-transmitter at NMDA receptors. Recent reports indicate that hypofunction of NMDA receptors may play an important role in the pathophysiology of schizophrenia, in particular the negative symptoms of the disease. Bitopertin is the first GlyT1 inhibitor to have a beneficial effect in schizophrenic patients.
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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