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SML4345

AZD3965

≥98% (HPLC)

Synonym(s):

5-​[[(4S)​-​4-​Hydroxy-​4-​methyl-​2-​isoxazolidinyl]​carbonyl]​-​3-​methyl-​1-​(1-​methylethyl)​-​6-​[[5-​methyl-​3-​(trifluoromethyl)​-​1H-​pyrazol-​4-​yl]​methyl]​-thieno[2,​3-​d]​pyrimidine-​2,​4(1H,​3H)​-​dione, AZD 3965, AZD-3965

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About This Item

Empirical Formula (Hill Notation):
C21H24F3N5O5S
CAS Number:
Molecular Weight:
515.51
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

AZD3965 is an orally bioavailable, potent and specific monocarboxylate transporter 1 (MCT1) inhibitor that causes increase of intracellular lactate, reduces cell proliferation and COR-L103 tumor growth in mice. AZD3965 treatment most likely induces a necrotic cell death, in hypoxic COR-L103 and NCI-H1048 tumors.


Storage Class

11 - Combustible Solids



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