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About This Item
Empirical Formula (Hill Notation):
C21H24F3N5O5S
CAS Number:
Molecular Weight:
515.51
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
AZD3965 is an orally bioavailable, potent and specific monocarboxylate transporter 1 (MCT1) inhibitor that causes increase of intracellular lactate, reduces cell proliferation and COR-L103 tumor growth in mice. AZD3965 treatment most likely induces a necrotic cell death, in hypoxic COR-L103 and NCI-H1048 tumors.
Storage Class
11 - Combustible Solids
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