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About This Item
Empirical Formula (Hill Notation):
C15H19N3O
CAS Number:
Molecular Weight:
257.33
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
UAMC-4821, a lipophilic radical-trapping antioxidant (RTA) and potent, orally bioavailable ferroptosis inhibitor, is designed to surpass the limitations of ferrostatin-1 and UAMC-3203. Demonstrating high potency (IC50 = 5.20 nM in HT-1080 cells, with FENIX assay confirming RTA activity), UAMC 4821 exhibits excellent oral bioavailability (63% in mice), low clearance, and high brain concentrations (123 ng/g after 24h, IV 10 mg/kg in mice), indicating superior ADME properties and blood-brain barrier penetration over earlier ferrostatins. Functionally, UAMC4821 directly neutralizes lipid peroxyl radicals within phospholipid bilayers, preventing membrane damage and ferroptotic death, thereby enhancing its attractiveness for CNS-targeted explorations.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1B
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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