Lasmiditan hemisuccinate

Name: Lasmiditan hemisuccinate
Brand: SIGMA

≥98% (HPLC)

Synonym(s):

2,4,6-Trifluoro-N-[6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl]benzamid hemisuccinate, 2,4,6-Trifluoro-N-[6-[(1-methylpiperidin-4-yl)carbonyl]pyridin-2yl]benzamide hemisuccinate, COL 144 hemisuccinate, COL-144 hemisuccinate, COL144 hemisuccinate, LY 573144 hemisuccinate, LY-573144 hemisuccinate, LY573144 hemisuccinate

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About This Item

Empirical Formula (Hill Notation):

C₃₈H₃₆F₆N₆O₄·C₄H₆O₄

CAS Number:

439239-92-6

Molecular Weight:

872.81

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

powder

drug control

USDEA Schedule V

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Description

Biochem/physiol Actions

Lasmiditan (COL-144 and LY573144) is an orally active, potent and selective high-affinity serotonin receptor 5-HT1F agonist (5-HT1F/1E Ki = 2.21/594 nM; 5-HT1A/B/C Ki >1 μM; 5-HT2A/B/C Ki >2 μM; 5-HT6/7 Ki >3 μM). Lasmiditan induces mitochondrial biogenesis (MB) in human glomerular endothelial cells and mouse glomerular endothelial cells (100 nM for 72h). Unlike the triptans, Lasmiditan is void of vasoconstrictor activity toward isolated human coronary arteries (up to 100 μM) or in anaesthetized female beagle dogs in vivo (4.13-11.13 mg/kg i.v.)