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SML4368

SerBut

≥98% (HPLC)

Synonym(s):

(2S)-2-Amino-3-(butanoyloxy)propanoic acid hydrochloride, O-(1-Oxobutyl)-L-serine, O-Butyryl-L-serine hydrochloride, O-Butyryl-L-Ser hydrpchloride

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About This Item

Empirical Formula (Hill Notation):
C7H13NO4·HCl
CAS Number:
1312366-50-9
Molecular Weight:
211.64
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

SerBut (O-butyryl-L-serine) is an orally available, serine-conjugated butyrate precursor with therapeutic efficacy against autoimmune arthritis and neuroinflammation in vivo in mouse models of collagen antibody-induced arthritis (CAIA) (anti-collagen mAb on day 0, LPS i.p. on day 3, daily 20 mg SerBut/mouse p.o. starting on day -14 or twice daily 25 mg SerBut/mouse p.o. starting on day 4) and experimental autoimmune encephalomyelitis (EAE) (MOG35-55/CFA + PTX on day 0, daily 24 mg SerBut/mouse p.o. starting on day 2 with or twice daily 24 mg SerBut/mouse p.o. starting on day 2 without 100 mM SerBut in drinking water throughout starting day -14).

Disclaimer

Hygroscopic Store with desiccant

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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