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About This Item
Empirical Formula (Hill Notation):
C15H15FN2O6S
CAS Number:
Molecular Weight:
370.35
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
The MFS03 (maleimido fluorosulfonyl) linker is a heterobifunctional covalent tether that converts affinity proteins (affibody and monobody) into irreversible therapeutics. MFS03 features a maleimide for cysteine conjugation and a bio-orthogonal aryl fluorosulfate warhead on a flexible spacer (2.92–17.7 Å), which initiates a proximity-enabled Sulfur(VI) Fluoride Exchange (SuFEx) reaction with target nucleophiles like histidine or lysine. On HER2/EGFR scaffolds, this covalent anchoring enhances therapeutic performance, yielding >2-fold tumor retention, 185% higher cellular uptake, and near-complete tumor inhibition. This permanent binding decouples pharmacodynamics from pharmacokinetics, boosting cytotoxicity 2.5- to 4.9-fold (to 0.31 nM) while maintaining a favorable biosafety profile.
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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