Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C35H50N2O6
CAS Number:
Molecular Weight:
594.78
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
protect from light
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Tryptophan-conjugated cholic acid (Trp-CA), a novel microbial amino-acid-conjugated bile acid, is an endogenous ligand for orphan GPCR MRGPRE (Mas-related G protein-coupled receptor family member E), revealing a non-itch glucose-regulatory function. CA-Trp activates MRGPRE (10 µM), initiating intestinal L-cell GLP-1 secretion via dual Gs-cAMP (EC50 = 9.6 µM) and β-arrestin-1-ALDOA pathways. The latter involves β-arrestin-1 recruitment and ALDOA phosphorylation. In vivo, oral Trp-CA improves glucose tolerance and ameliorates obesity in HFD-fed diabetic mice, highlighting its potential as a gut-localized T2D therapeutic.
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.