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About This Item
Empirical Formula (Hill Notation):
C22H21N5O2 · xH2O
Molecular Weight:
387.43 (anhydrous basis)
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
gray to very dark black-purple
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
EI-52, a benzimidazole, is a potent and selective inhibitor of ERK-MYD88 interaction (IC50 = 3.1μM). EI-52 binds to the ERK D-recruitment site (DRS) without influence on ERK (ERK1 and ERK2) kinase activity and potently disrupts ERK-MYD88 interaction leading to immunogenic apoptosis specific to cancer cells. ERK-MYD88 PPI inhibitor EI-52 exhibits antitumor activity in mice models and in patient-derived tumor organoids. EI-52 induces an anti-tumor T cell response in mice in vivo.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1B
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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