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SML4439

Diazirine-PEG3-Biotin

≥98% (HPLC)

Synonym(s):

18-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-14-oxo-N-[[4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]methyl]- 4,7,10-trioxa-13-azaoctadecanamide, Biotin-Diazirine, Biotin-PEG3-Diazirine, Biotin-PEG3-Dz

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About This Item

Empirical Formula (Hill Notation):
C28H39F3N6O6S
CAS Number:
2845211-64-3
Molecular Weight:
644.71
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

Diazirine-PEG3-Biotin, a membrane-impermeable micromapping (µMAP) photo-proximity label, enables light-activated plasma membrane biotinylation. Diazirine′s spatiotemporal control and indiscriminate covalent insertion, via photoactivation (Dexter transfer), rapidly generate short-lived (<2 ns) triplet carbenes for controlled, high-resolution (2-120 nm radii, photocatalyst dependent) tagging of proximal membrane biomolecules. PEG3 linker enhances solubility and delivery, restricting diffusion for refined protein interaction mapping, crucial to map interactomes. Biotin (affinity handle) then enables efficient streptavidin/avidin enrichment and quantitative proteomics of the precisely labeled protein microenvironment.

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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