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About This Item
Empirical Formula (Hill Notation):
C24H40O3
CAS Number:
Molecular Weight:
376.57
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
Lithocholic acid (LCA), a secondary bile acid absorbed into the bloodstream and transported to muscle, acts as a TGR5 agonist and endogenous calorie restriction mediator, indirectly activating SIRT1 via TUB Like Protein 3 (TULP3) to engage AMPK through v-ATPase inhibition. This cascade improves metabolic parameters and stress resistance, raises GLP-1, and notably exhibits antineoplastic effects in pancreatic adenocarcinoma by inducing oxidative/nitrosative stress via CAR, FXR, and VDR nuclear receptors, inhibiting proliferation, EMT, and stem cell markers while upregulating mitochondrial oxidative phosphorylation. LCA extends lifespan in model organisms and enhances grip strength and insulin sensitivity in aged mice, underscoring its broad therapeutic potential in aging and oncology.
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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