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About This Item
Empirical Formula (Hill Notation):
C6H9NO2
CAS Number:
Molecular Weight:
127.14
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
-10 to -25°C
Biochem/physiol Actions
L-Homopropargylglycine (HPG) is a cell-permeable, non-canonical amino acid and structural analog of L-methionine, possessing a terminal alkyne (–C≡CH) group as a bioorthogonal handle. This structure is recognized by the native, wild-type methionyl-tRNA synthetase (MetRS), which mediates its incorporation into nascent polypeptide chains at methionine positions during ribosomal synthesis. Because MetRS promiscuously charges HPG onto tRNAᴹᵉᵗ in most cell types, this results in broad, non-specific labeling of the translatome. The incorporated alkyne handle serves as a versatile platform for covalent ligation via click chemistry, enabling either fluorescent visualization (FUNCAT) or affinity enrichment (BONCAT) of newly synthesized proteins. While lacking cell-type specificity, HPG provides an accessible and powerful tool for monitoring global proteome dynamics.
Disclaimer
Hygroscopic, Store with desiccant
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Self-react. C
Storage Class
5.2 - Organic peroxides and self-reacting hazardous materials
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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