Skip to Content
MilliporeSigma

Key Documents

View All Documentation

SML4482

AF64394

≥97% (HPLC)

Synonym(s):

N-[[4-Chloro-2-(1-methylethoxy)phenyl]methyl]-5-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):
C21H20ClN5O
CAS Number:
1637300-25-4
Molecular Weight:
393.87
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
powder
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Segment

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

Biochem/physiol Actions

AF64394 is a potent and selective inverse agonist for the G protein-coupled receptor GPR3 (IC50 = 0.5 µM GPR3, 7.9 µM GPR6 and 12 µM GPR12) that potently inhibits cAMP accumulation in HEK293 cells. It appears that AF64394 binds to the transmembrane dimer interface and functions as a negative allosteric modulator (NAM) specifically targeting dimeric GPR3.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library