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About This Item
Empirical Formula (Hill Notation):
C21H24N2O4
CAS Number:
Molecular Weight:
368.43
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
HOR1-C59 is a cell-permeable, stable and highly selective full agonist of the ectopic olfactory receptor Or5v1/Olfr110, exhibiting approximately 2-fold greater potency than the endogenous oxylipin 12(S)-HEPE (EC50 ≈ 7.12 nM). Mechanistically, HOR1-C59 selectively drives Gs-protein coupling to trigger the cAMP-PKA cascade in hepatocytes, resulting in the robust phosphorylation (Thr51/Thr53) and nuclear translocation of transcription factor ATF2. Once in the nucleus, ATF2 binds the Cpt1α promoter (-1761 to -2000 bp region) to upregulate the expression of Cpt1α. Through this direct engagement of mitochondrial β-oxidation machinery, HOR1-C59 effectively reverses diet-induced obesity, hepatic steatosis, and insulin resistance in an Olfr110-dependent manner.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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