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holo-Transferrin bovine

Name: holo-Transferrin bovine
Brand: SIGMA

Synonym(s):

Siderophilin, Siderophilin, iron-saturated

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About This Item

CAS Number:

11096-37-0

UNSPSC Code:

12352202

EC Number:

234-318-8

NACRES:

NA.61

MDL number:

MFCD00131337

eCl@ss:

34058011

Form:

powder

Assay:

97-100% (agarose gel electrophoresis)

Biological source:

bovine

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Properties

biological source

bovine

Quality Segment

200

assay

97-100% (agarose gel electrophoresis)

form

powder

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

Q29443

storage temp.

2-8°C

Gene Information

bovine ... TF(280705)

Description

General description

Holo-Transferrin is an iron transporting glycoprotein and belongs to metalloprotein class. The gene encoding transferrin is mapped to bovine chromosome 1.

Application

Holo-Transferrin bovine has been used:

as a RPMI-1640 medium supplement for culturing cancer cell lines
as a component of visceral fat differentiation medium for the pre-adipocytes primary cell culture
to test the influence of iron-saturation complex on the growth of Malassezia pachydermatis
as a standard for strong anion exchange (SAX) reactor measurements

Biochem/physiol Actions

Studies show that treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.

Holo-Transferrin (holo-Tf) or the iron bound transferrin functions as an iron sequester and is crucial for defense against microbial infections. Transferrin is used as a model system for understanding the kinetics and dynamics of protein structure based interactions. It is a potential candidate for delivery studies for its ability to cross the blood-brain barrier. The interaction of holo-Tf with thrombin is implicated in the pathogenesis of intracerebral hemorrhage. Polymorphisms in the bovine transferrin gene has led to the generation of 10 variant transferrin protein.

Analysis Note

Purity by agarose gel electrophoresis.

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This Item	T1283	T1428	T0178
Sigma-Aldrich T1408 holo-Transferrin bovine	Sigma-Aldrich T1283 holo-Transferrin bovine	Sigma-Aldrich T1428 apo-Transferrin bovine	Sigma-Aldrich T0178 apo-Transferrin bovine
description -	description Iron-saturated, BioReagent, suitable for cell culture	description BioReagent, suitable for cell culture, ≥98%	description ≥98%
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
biological source bovine	biological source -	biological source bovine	biological source bovine
assay 97-100% (agarose gel electrophoresis)	assay 97-100% (agarose gel electrophoresis)	assay ≥98%	assay ≥98%
form powder	form powder	form powder	form powder
UniProt accession no. Q29443	UniProt accession no. Q29443	UniProt accession no. Q29443	UniProt accession no. Q29443
Gene Information bovine ... TF(280705)	Gene Information bovine ... TF(280705)	Gene Information bovine ... TF(280705)	Gene Information bovine ... TF(280705)

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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