The product is advised to be dissolved in anoxic water. The use of distilled water is not recommended, as it can absorb more oxygen from the atmosphere.
T4425
(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride
≥98% (HPLC), powder
Synonyme(s) :
(6R)-BH4
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| À vous/Référence | Disponibilité | Prix |
|---|---|---|
5 mg | Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit. | 95,90 € |
25 mg | Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit. | 267,00 € |
100 mg | Veuillez contacter notre Service Clients pour connaître la disponibilité de ce produit. | 887,00 € |
A propos de cet article
Formule empirique (notation de Hill) :
C9H15N5O3 · 2HCl
Numéro CAS:
Poids moléculaire :
314.17
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
95,90 €
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Laissez-nous vous aiderNom du produit
(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride,
Quality Segment
solubility
water, oxygen free: soluble 19.60-20.40 mg/mL, clear to slightly hazy, colorless to faintly yellow
storage temp.
−20°C
SMILES string
Cl.Cl.C[C@H](O)[C@H](O)[C@H]1CNC2=C(N1)C(=O)NC(N)=N2
InChI
1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1
InChI key
RKSUYBCOVNCALL-NTVURLEBSA-N
Gene Information
human ... PAH(5053)
General description
Tetrahydrobiopterin is a natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthase and alkylglycerol monooxygenase.
Application
(6R)-BH4 has been used as a buffer component for assaying tyrosine hydroxylase enzyme activity in mouse brain tissues. (6R)-BH4 has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay.
Biochem/physiol Actions
Lack of tetrahydrobiopterin may cause hyperphenylalaninemia. Diseases like, Parkinson′s, autism, depression and Alzheimer′s shows low concentration of tetrahydrobiopterin in the cerebrospinal fluid. This coenzyme participates in dopamine (DA) synthesis.
Features and Benefits
This compound is featured on the Dopamine, Norepinephrine and Epinephrine Synthesis and Nitric Oxide Synthases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
(6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride ((6R)-BH4 ) is soluble in oxygen free water at 19.60 - 20.40 mg/ml and yields a clear to slightly hazy, colorless to faint yellow solution.
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Cet article | |||
|---|---|---|---|
| description - | description A cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC50 = 300 nM) compared to the endothelial enzyme (IC50 = 5.4 µM). | description NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase (IC50 = 3-4 µM). | description Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 µM). |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 10-30°C |
| solubility water, oxygen free: soluble 19.60-20.40 mg/mL, clear to slightly hazy, colorless to faintly yellow | solubility water: 50 mg/mL | solubility methanol: soluble, water: soluble | solubility methanol: 10 mg/mL, water: 50 mg/mL |
| Gene Information human ... PAH(5053) | Gene Information - | Gene Information - | Gene Information - |
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Is the product T4425 (CAS 69056-38-8) soluble in distilled water?
1 answer-
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How should a solution of (6R)-5,6,7,8-tetrahydrobiopterin (hydrochloride) be stored? How long is it good for?
1 answer-
Tetrahydrobiopterin reacts with oxygen, particularly in neutral and alkaline solutions. The product should be reconstituted in oxygen-free water. Tetrahydrobiopterin solutions become yellow but are stable for several weeks at -20°C when prepared at 20-40 mg/mL in 0.1 N HCl.
Please review the product data sheet for more information on this product:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/277/129/t4425pis.pdfHelpful?
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