UC167
Oxidized Nifedipine
powder, ~95% (HPLC)
Synonym(s):
2,6-Dimethyl-4-(2´-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester
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About This Item
Empirical Formula (Hill Notation):
C17H16N2O6
CAS Number:
Molecular Weight:
344.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
Assay:
~95% (HPLC)
Form:
powder
assay
~95% (HPLC)
Quality Segment
form
powder
color
yellow
mp
100-105 °C
storage temp.
2-8°C
SMILES string
COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c2ccccc2[N+]([O-])=O
InChI
1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3
InChI key
UMQHJQGNGLQJPF-UHFFFAOYSA-N
Application
Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons[1].
Oxidized Nifedipine may be used:
- to study enzyme kinetics using UV high-performance liquid chromatography (UV-HPLC)
- as a standard in calibration curve preparation in high-performance liquid chromatography (HPLC) for the quantification of cytochrome P450 3A4 (CYP3A4)-mediated nifedipine oxidation in human microsomes[2]
- in nifedipine metabolism activity assay of Hep G2 cells transfected with hepatocyte nuclear factor-1α(HNF1α)[3]
Biochem/physiol Actions
CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.
Nifedipine is a dihydropyridine derivative[4] and a calcium channel blocker.[5] It is used in treating hypertension and angina pectoris.[4] Oxidized Nifedipine is an oxidation product of nifedipine generated either by exposure to UV or day light.[5] The enzyme cytochrome P450 3A (CYP3A4) metabolizes nifedipine.[3]
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ~95% (HPLC) | assay ≥98% (HPLC) | assay ≥98% | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. room temp |
| color yellow | color yellow | color yellow | color yellow |
| mp 100-105 °C | mp - | mp - | mp - |
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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