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1270480

USP

Fingolimod Hydrochloride

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

FTY720, 2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diol hydrochloride, Fingolimod hydrochloride

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Size/SKUAvailabilityPrice
300 mg
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€3,690.00

About This Item

Empirical Formula (Hill Notation):
C19H33NO2 · HCl
CAS Number:
162359-56-0
Molecular Weight:
343.93
MDL number:
MFCD00939512
UNSPSC Code:
41116107
NACRES:
NA.24

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biological source

synthetic

grade

pharmaceutical primary standard

agency

USP

API family

fingolimod

form

powder

manufacturer/tradename

USP

storage condition

protect from light

color

white

solubility

DMSO: soluble, ethyl acetate: soluble, water: soluble

application(s)

pharmaceutical

storage temp.

2-8°C

SMILES string

Cl.NC(CO)(CO)CCc1ccc(cc1)CCCCCCCC

InChI

1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H

InChI key

SWZTYAVBMYWFGS-UHFFFAOYSA-N

General description

Find answers to frequently asked questions on USP products in USP FAQs.
Fingolimod Hydrochloride (fingolimod HCl), an S1P-receptor modulator, belongs to the class of synthetic glucocorticoid steroid drugs.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Fingolimod Hydrochloride USP reference standard may be used to quantify the analyte in gel, capsule and other pharmaceutical formulations, active pharmaceutical ingredient (API) and pharmaceutical dosage forms by liquid chromatography (LC) based techniques.

Biochem/physiol Actions

FTY720 is an immunomodulating drug and sphingosine 1-phosphate (S1P) receptor modulator. Phosphorylation of FTY270 by sphingosine kinase causes S1P1R internalization, which sequesters lymphocytes in lymph nodes, preventing them from taking part in an autoimmune response. Clinically, it has been approved for the treatment of multiple sclerosis (MS). It has also been shown to block and reverse paclitaxel-induced chemotherapy induced peripheral neuropathy (CIPN) through S1PR inhibition as well as inhibit the activity of histone deacetylases in the hippocampus of mouse brains, thereby modulating memory.
FTY720, an immunomodulating drug, acts as a sphingosine 1-phosphate (S1P) receptor modulator.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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FTY720 ≥98% (HPLC)

Sigma-Aldrich

SML0700

FTY720

description

United States Pharmacopeia (USP) Reference Standard

description

European Pharmacopoeia (EP) Reference Standard

description

-

description

≥98% (HPLC)

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

grade

-

manufacturer/tradename

USP

manufacturer/tradename

EDQM

manufacturer/tradename

-

manufacturer/tradename

-

application(s)

pharmaceutical

application(s)

pharmaceutical

application(s)

pharmaceutical small molecule

application(s)

-

form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-30°C

storage temp.

−20°C

biological source

synthetic

biological source

synthetic

biological source

-

biological source

-

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Hazard Classifications

STOT RE 2

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H373

target_organs

Immune system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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