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Merck

09963

(Hydroxypropyl)methyl cellulose

Synonym(s):

2-Hydroxypropyl methyl cellulose ether

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About This Item

CAS Number:
9004-65-3
UNSPSC Code:
12352201
NACRES:
NA.25
MDL number:
MFCD00131360

Key Documents

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SMILES string

O3[C@H]([C@@H]([C@H]([C@@H]([C@H]3COCC(O)C)OCC(O)C)OCC(O)C)OCC(O)C)O[C@@H]4[C@H](O[C@H]([C@@H]([C@H]4OCC(O)C)OCC(O)C)OCC(O)C)COCC(O)C.O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1COC)OC)OC)OC)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2OC)OC)OC)COC

InChI

1S/C36H70O19.C20H38O11/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41;1-21-9-11-13(23-3)15(24-4)18(27-7)20(30-11)31-14-12(10-22-2)29-19(28-

InChI key

PUSNGFYSTWMJSK-GSZQVNRLSA-N

form

powder

composition

hydroxylpropoxyl content, ~9%

color

faint beige

viscosity

~15 mPa.s, 2 % in H2O(25 °C)

solubility

water: 100 mg/10 mL, clear, colorless

storage temp.

room temp

Quality Level

100

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Show Differences

1 of 4

This Item
423181423173H9262
(Hydroxypropyl)methyl cellulose

Sigma-Aldrich

09963

(Hydroxypropyl)methyl cellulose

(Hydroxypropyl)methyl cellulose average Mn ~90,000

Sigma-Aldrich

423181

(Hydroxypropyl)methyl cellulose

(Hydroxypropyl)methyl cellulose average Mn ~120,000

Sigma-Aldrich

423173

(Hydroxypropyl)methyl cellulose

(Hydroxypropyl)methyl cellulose viscosity 80-120 cP, 2 % in H2O(20 °C)(lit.)

Sigma-Aldrich

H9262

(Hydroxypropyl)methyl cellulose

solubility

water: 100 mg/10 mL, clear, colorless

solubility

-

solubility

-

solubility

-

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

form

powder

form

powder or crystals

form

powder

form

powder

storage temp.

room temp

storage temp.

-

storage temp.

-

storage temp.

-

color

faint beige

color

-

color

-

color

beige

composition

hydroxylpropoxyl content, ~9%

composition

-

composition

-

composition

-

Application

(Hydroxypropyl)methyl cellulose (HPMC), an inert viscoelastic polymer is used as an emulsifier, thickening and suspending agent similar to animal gelatin. HPMC is used in the development of controlled-delivery medicament.
Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.

Features and Benefits

Dissolves in water, undergoes reversible gelation upon heating, non-ionic, does not complex with ionic species and is surface active and enzyme resistant. Solutions are pseudoplastic.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN2238
BCCK8355
BCCH7772
BCCD6210
BCCC1820

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Punit P Shah et al.
Biomaterials, 33(5), 1607-1617 (2011-11-29)
The aim of this study was to develop an effective drug delivery system for the simultaneous topical delivery of two anti-inflammatory drugs, spantide II (SP) and ketoprofen (KP). To achieve this primary goal, we have developed a skin permeating nanogel
Lucas Sievens-Figueroa et al.
International journal of pharmaceutics, 423(2), 496-508 (2011-12-20)
The design and feasibility of a simple process of incorporating stable nanoparticles into edible polymer films is demonstrated with the goal of enhancing the dissolution rate of poorly water soluble drugs. Nanosuspensions produced from wet stirred media milling (WSMM) were
Jane W Agger et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(17), 6287-6292 (2014-04-16)
The recently discovered lytic polysaccharide monooxygenases (LPMOs) are known to carry out oxidative cleavage of glycoside bonds in chitin and cellulose, thus boosting the activity of well-known hydrolytic depolymerizing enzymes. Because biomass-degrading microorganisms tend to produce a plethora of LPMOs
Somayeh Bahrami et al.
Veterinary parasitology, 203(1-2), 43-50 (2014-03-19)
Fasciola gigantica is a parasitic helminth that predominantly infects the liver and bile ducts of cattle and causes great losses of cattle production in the southwestern regions of Iran. The purpose of the present study was to find out the
Jeonghoon Han et al.
Aquatic toxicology (Amsterdam, Netherlands), 152, 308-317 (2014-05-13)
In this study, we investigated the effects of the water-accommodated fraction (WAF) of crude oil on the development and reproduction of the intertidal copepod Tigriopus japonicus through life-cycle experiments. Furthermore, we investigated the mechanisms underlying the toxic effects of WAF
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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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