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Merck

61360

Lactulose

≥98.0% (HPLC)

Synonym(s):

4-O-β-D-Galactopyranosyl-D-fructofuranose, 4-O-β-D-Galactopyranosyl-D-fructose

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About This Item

Empirical Formula (Hill Notation):
C12H22O11
CAS Number:
4618-18-2
Molecular Weight:
342.30
Beilstein:
93773
EC Number:
225-027-7
MDL number:
MFCD00151469
UNSPSC Code:
12352201
PubChem Substance ID:
57651848
NACRES:
NA.25

Key Documents

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Quality Level

100

Assay

≥98.0% (HPLC)

form

solid

optical activity

[α]20/D −48±2°, 24 hr, c = 1% in H2O

color

white to off-white

mp

169  °C ((336 °F ))

storage temp.

room temp

SMILES string

OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@@](O)(CO)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O

InChI

1S/C12H22O11/c13-1-4-6(16)7(17)8(18)11(21-4)22-9-5(2-14)23-12(20,3-15)10(9)19/h4-11,13-20H,1-3H2/t4-,5-,6+,7+,8-,9-,10+,11+,12+/m1/s1

InChI key

JCQLYHFGKNRPGE-WJONTELPSA-N

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1 of 4

This Item
1356803Y0001510427584
Lactulose ≥98.0% (HPLC)

Sigma-Aldrich

61360

Lactulose

Lactulose United States Pharmacopeia (USP) Reference Standard

USP

1356803

Lactulose

Lactulose for peak identification European Pharmacopoeia (EP) Reference Standard

Y0001510

Lactulose for peak identification

Lactulose A β-galactosidase substrate.

Millipore

427584

Lactulose

assay

≥98.0% (HPLC)

assay

-

assay

-

assay

≥97% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

form

solid

form

-

form

-

form

solid

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

15-25°C

mp

169  °C ((336 °F ))

mp

-

mp

-

mp

-

color

white to off-white

color

-

color

-

color

white

General description

Lactulose is a synthetic derivative of lactose. It is made up of one molecule of galactose and one molecule of fructose.[1]

Application

Lactulose has been used in the preparation of milk.[2]
Lactulose, a disaccharide composed of fructose and galactose units, is used as an osmolyte that relieves constipation and supports probiotic processes in the intestine and colon. Lactulose helps stabilize blood glucose and insulin levels.

Biochem/physiol Actions

Lactulose helps to decrease the concentration of blood ammonia in the treatment of hepatic encephalopathy. It is also used to treat constipation as an osmotic laxative. This non-absorbable disaccharide is catabolized through the bacterial flora to short chain fatty acids.[3] The enzymes of the mammalian digestive tract do not have the ability to digest lactulose.[1]

Other Notes

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN5302
BCCM6933
BCCM6930
BCCM6932
BCCL4994

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Use of lactulose as prebiotic and its influence on the growth, acidification profile and viable counts of different probiotics in fermented skim milk
Oliveira R P D S, et al.
International Journal of Food Microbiology, 145(1), 22-27 (2011)
Gastrointestinal drugs
Small Animal Clinical Pharmacology, 469-497 (2008)
Lactulose enemas in the treatment of hepatic encephalopathy. Do we help or harm?
de Lorenzo-Pinto A, et al.
Revista espa?ola de Enfermedades Digestivas : Organo Oficial de la Sociedad Espa?ola de Patologia Digestiva (2017)
Meiyan Wang et al.
Journal of agricultural and food chemistry, 66(12), 3155-3160 (2018-03-13)
Aging and oxidative-related events are closely associated with the oxidative damages induced by excess reactive oxygen species (ROS). The phytochemicals nobiletin (NBT) and tangeretin (TAN) and their 5-demethylated derivatives 5-demethylnobiletin (5-DN) and 5-demethyltangeretin (5-DT) are the representative polymethoxyflavone (PMF) compounds
Tara Raftery et al.
United European gastroenterology journal, 3(3), 294-302 (2015-07-03)
Vitamin D (vitD) supplementation may prolong remission in Crohn's disease (CD); however, the clinical efficacy and mechanisms are unclear. To determine changes in intestinal permeability (IP), antimicrobial peptide (AMP) concentrations and disease markers in CD, in response to vitD supplementation.
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